Given the limited data, no firm conclusions can be drawn with regards to the safety of use of these antiepileptic drugs during pregnancy and the risks remain unclear. Non-clinical studies report reduced fetal body weights in rats and rabbits following exposure to pregabalin during pregnancy but this occurred at plasma concentrations sufficiently higher than human therapeutic concentrations. Dosing of pregabalin during gestation and lactation induced offspring developmental toxicity in rats at exposures 5 times or greater than the maximum recommended human exposure. A further study by Trivedi et al 2018 in the Kerala Pregnancy Registry investigated spontaneous fetal loss in pregnancies exposed to phenytoin compared with pregnancies in non-exposed women with epilepsy.
- A safety signal is defined as the information suggesting a new potential association or new aspects of a known association between medicines and adverse event(s) that warrant further investigation.
- When the person’s awareness of what is happening around them is affected at any time during the seizure, it’s called a focal impaired awareness seizure.
- We are working alongside professional teams from an array of backgrounds to suit the developer and home owner needs.
- Several months later, they unstitched the eye and found that the kittens had gone blind in one eye.
- Gardner emphasises that we all have at least seven intelligences and each can be improved with practise.
Neurobehavioural effects
These can have different causes, including a person’s genetics, a structural change in the brain, or as a result of other health conditions. The Triune Brain We have three-brains-in-one which represents an evolutionary inheritance. This controls our basic instincts – breathing, heart rate, sense of territory. This controls our emotions, sexuality, sleep and immune system, and plays an important role in long term memory. This comprises a two-sided cerebrum the so-called left and right brain linked by a massive bundle of nerves, the corpus callosum, comprising some 200 million fibres.
The Commission on Human Medicines has reviewed the available safety data for epilepsy medicines during pregnancy. This review was initiated in the context of the known harms of valproate in pregnancy. We thus go on to live out our lives without much knowledge of how we learn, how our mind or memory operates and therefore with little idea about how to keep the brain holistically active and healthy. The evidence suggests that if we have this know-how, and use it, our brain does not deteriorate with age and our mental abilities can continually improve. A Body-Mind fitness programme is therefore a programme for life, living and longevity. The Brain Cell Within the brain is at least 10 billion brain cells or neurons.
Generalised seizures
At that time, similar reviews had not recently been done for the other epilepsy medicines. The Commission on Human Medicines recommended that the MHRA should review whether the available data raises any new safety concerns or changes current understanding about the safety of other epilepsy medicines during pregnancy. Epilepsy medicines (also known as antiepileptic drugs and antiseizure medicines) are medicines that treat epilepsy. For around 2 in 3 people with epilepsy, their seizures are controlled with one or more epilepsy medicines.
Sensory Processing DifficultiesThis is a general term meaning that the challenges a person may face, could be due to how the brain is processing information received from the senses. All the incoming information to the brain comes via the senses, so you really need a bit more information, as all it essentially means is that the difficulties are due to how the brain processes the incoming information from the senses, which is not specific enough to mean much. Challenging Behaviour / Distressed BehaviourThese terms are sometimes used when a person does not meet the criteria for another condition, typically autism, yet has some of the behaviours cerebrumiq affecting both the person and possibly others around them. The behaviours can be very similar to autism, and either milder, or without the other behaviours.See also, Autism, above. Hubel and Wiesel carried out an experiment on kittens and adults cats in 1963 which proved that the visual cortex develops during a critical period early in life.